Parental Family Structure, Helicobacter Pylori, and Gastric Adenocarcinoma

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Parental Family Structure, Helicobacter Pylori, and Gastric Adenocarcinoma

T he study of family of origin (parental family), as contrasted to family of procreation, originally received attention from epidemiology in the context of childhood infectious diseases. Two aspects of parental family have been intensely investigated: sibship size and birth order [1,2]. Larger sibship size increases the likelihood of introduction and spread of infectious agents within the famil...

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Helicobacter pylori infection, thought to be causally related to chronic gastritis, may also be associated with an increased risk of gastric cancer. To determine whether an association with gastric cancer does exist, we retrospectively evaluated serum samples from 69 patients with histologically confirmed gastric adenocarcinoma (32 with cancer at the cardia and 37 with cancer at other sites) an...

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Animal studies showed that male gastric tissues respond more rapidly to Helicobacter pylori (H.pylori) infection but the possible mechanisms remained unclear. There is no data about gender specific activity of Androgen receptor (AR) as an independent unfavorable prognostic factor in gastric cancer and its interactions with H.pylori and angiogenesis in both genders. To compare the pathogenesis o...

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Helicobacter pylori and gastric cancer.

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ژورنال

عنوان ژورنال: PLoS Medicine

سال: 2007

ISSN: 1549-1676

DOI: 10.1371/journal.pmed.0040025